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12 Principles of Clinical Pharmacology Most tissues Nonspecific binding Plasma Protein bound Free Biophase Recept or binding Elimination Prescribed dose Compliance Absorption Renal excretion Distribution Effect 40 35 30 25 20 15 10 5 0 Nontoxic (131) Toxic (48) 0 1 2 3 4 5 6 7 8 8 [DIGOXIN] (ngmL) Metabolism FIGURE 2.

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