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1 108). 2) Z2(s) all-or-none characteristic 110 anion-selective 110111 conductors or resistors in electrical equivalent circuit 134 behavior as rectifier 111112 binding of drugs corex toxins and functional state 115 calcium closely related to Na channels 164166 concentration at presynaptic terminal of neuromuscular junction 259 molecular bases for diversity 257 -sensitive K channels 621 622 types 256257 and voltage-dependent K, and afterhyperpolarization in paroxysmal depolarizing shift 919 calcium-activated K channel 158 cation-selective 110 cGMP-gated during phototransduction 512 in photoreceptors 511 during darkness 513 chimeric 117 chloride effect of opening on EPSP 217 mechanism for inhibition of postsynaptic cell 29 217 cloning and sequencing of genes for 116 combinations of and response to excitatory input 160 common ancestor for genes of Na, K, and Ca2 channels 164166 comparison of synaptic excitation produced by opening and closing 240 conductance and ion permeation 111112 contribute to determination of ionic permeability properties of cell membrane 106107 control rapid changes in membrane potential 123 current linearly related to voltage 110 current flow as nonlinear function of driving force 111112 delayed rectifier 158 different combinations expressed 33 differing selectivities 123 direct gating 230 mediated by ionotropic receptors 184 direct modulation by G proteins 244248 dissociation constant 112 each acting as conductor and battery in parallel 134 effect of drugs and toxins on gating 114 end-plate motor neuron opens to excite muscle 190 permeability to Na and K 192 evolutionary conservation of structure and function 117 factors contributing to selectivity of 163164 families of 118 flux of ions through is passive 110112 functional methods of study 109110 functional properties can change over course of development 120 120 functional states goto G protein-regulated inward-rectifying K 248 G-protein-coupled inward rectifying, activation by ACh 247 GABA, role in disease 219 GABA-A chloride, structural model 1223 GABA-gated, recording of current 217 GABA-gated Cl- activation of and presynaptic inhibition 275 mediate inhibitory synaptic action 214219 opening can cause excitation in brain cells 219 gap-junction, structure 118119 118 gated 107 125 directly or indirectly by postsynaptic receptors 185 gating 112 in hair cells 617 physical models for 113 types of stimuli controlling 113 glutamate-gated and conducting Na and K.

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38 cm3 mol1 at Tliq 245 K. However, a report has suggested that it may have contributed to uterine atony, with resulting excessive hemorrhage when given prophylactically after a cesarean section (269), and muscle weakness associated with its oral prophylactic use in a patient with compromised respiratory function is reported to have exacerbated postoperative respiratory depression stamppa such an extent that artificial ventilation was required (SEDA-14, 114) (270).

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